Adaptive exponential integrate-and-fire model as an effective description of neuronal activity

by Romain Brette, Wulfram Gerstner
Abstract:
We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (+/-2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.
Reference:
Romain Brette, Wulfram Gerstner, 2005.Adaptive exponential integrate-and-fire model as an effective description of neuronal activity, Journal of neurophysiology, volume 94.
Bibtex Entry:
@article{Brette2005,
 abstract = {We introduce a two-dimensional integrate-and-fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes (+/-2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.},
 author = {Brette, Romain
and Gerstner, Wulfram},
 day = {13},
 doi = {10.1152/jn.00686.2005},
 issn = {0022-3077},
 journal = {Journal of neurophysiology},
 keyword = {Synaptic Transmission},
 language = {eng},
 month = {Nov},
 number = {5},
 pages = {3637--3642},
 pmid = {16014787},
 title = {Adaptive exponential integrate-and-fire model as an effective description of neuronal activity.},
 volume = {94},
 year = {2005}
}